- Liposomes: Methods and Protocols, Volume 2: Biological Membrane Models / Edition 1
- Liposomes as Potential Drug Carrier Systems for Drug Delivery
- Lipid-Protein Interactions - Methods and Protocols | Jörg Kleinschmidt | Springer
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Liposomes: Methods and Protocols, Volume 2: Biological Membrane Models / Edition 1
Buy eBook. Buy Hardcover. Buy Softcover. FAQ Policy. About this book In vitro utilization of liposomes holds great potential as a powerful tool for drug targeting, gene transport across plasma and nuclear membranes, and enzyme therapy for patients with genetic disorders. Show all. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
This article has been cited by other articles in PMC. Abstract Since their discovery in the s, liposomes have been studied in depth, and they continue to constitute a field of intense research.
Keywords: liposomes, nanomedicine, drug delivery, ultrastructure. Introduction Liposomes were discovered by Alec D Bangham in the s at the Babraham Institute, University of Cambridge, and consist of single or multiple concentric lipid bilayers encapsulating an aqueous compartment Figure 1. Open in a separate window. Figure 1. The physicochemistry of liposomes The adequacy of liposomes as a carrier system for drugs strictly depends on the physicochemical properties of their membranes, on the nature of their components, on their size, surface charge, and lipid organization.
Methods for the preparation of liposomes There are many different methods for the preparation of liposomes.
Liposomes as nanocarriers for drug delivery Despite considerable progress in recent years, the diagnosis and treatment of various diseases, especially cancer, continue to present constraints, such as low sensitivity or specificity, drug toxicity, and severe side effects. Effect of size on liposome fate Pathological tissues, such as inflammatory or solid tumor tissues, are characterized by increased vascular permeability. Figure 2. Targeting of nanomedicines by the enhanced permeability and retention EPR effect.
Pharmacokinetics of liposomes The pharmacokinetics of liposomes focuses on their distribution throughout the body fluids and tissues and their metabolism. Charged liposomes When a liposome interacts with a cell, the delivery of the drug and its distribution in the target cell can occur in several ways.
Figure 3. Liposome—cell interaction. Figure 4. Figure 5. Stimuli-responsive liposomes Conventional and long-circulating liposomes may present a slow release of the loaded drug or may be unable to fuse with the endosome after internalization. Liposomes in theranostics Nanotechnology gives the opportunity to assemble therapeutic and diagnostic agents as a single theranostic platform, ie, a molecular platform that simultaneously integrates diagnosis and therapy.
Table 2 Liposomes on market or in clinical trials. Conclusion Due to their biocompatibility and biodegradability, liposomes were the first drug-delivery system approved for clinical purposes. Footnotes Disclosure The authors report no conflicts of interest in this work. References 1. Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope.
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New York: Plenum; The big picture on nanomedicine: the state of investigational and approved nanomedicine products. Drug delivery vehicles on a nano-engineering perspective. Fanciullino R, Ciccolini J.
- Lipid-Protein Interactions - Methods and Protocols | Jörg Kleinschmidt | Springer.
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- Liposome Methods and Protocols | SpringerLink.
Liposome-encapsulated anticancer drugs: still waiting for the magic bullet? Curr Med Chem. Imparting size, shape, and composition control of materials for nanomedicine. Chem Soc Rev. Papahadjopoulos D, Kimelberg HK. Progress in Surface Science. Oxford: Pergamon; Phospholipid vesicles liposomes as models for biological membranes: their properties and interactions with cholesterol and proteins; pp. Lipid polymorphisms and membrane shape.
Liposomes as Potential Drug Carrier Systems for Drug Delivery
Cold Spring Harb Perspect Biol. Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential. Drug encapsulation and release from multilamellar and unilamellar liposomes. Int J Pharm. Nebulization of liposomes. The effects of size and modeling of solute release profiles. Pharm Res. Schechter E. Aspects structuraux et fonctionnels. In: Schechter E, Rossignol B, editors.
Lipid-Protein Interactions - Methods and Protocols | Jörg Kleinschmidt | Springer
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Liposome technology for industrial purposes. J Drug Deliv. Diffusion of univalent ions across the lamellae of swollen phospholipids. New RC. Preparation of liposomes. In: New RC, editor. Liposomes: A Practical Approach. New York: Oxford University Press; Szoka F, Papahadjopoulos D.